Fra Angelico was one of the monk painters of the early Renaissance period in the Florentine School of Painting in Italy, and he achieved remarkable proficiency in the field of painting art. His series of paintings, including "The Annunciation" blend the elegant decorative nature of post-Gothic art with the realistic characteristics of the Renaissance period. With the highquality development of modern painting art, research on Fra Angelico's "The Annunciation" has become one of the hotspots. The perspective and lighting effects in it also play an important role and have value for the development of contemporary painting art. Furthermore, the application of color in Fra Angelico's "The Annunciation" perfectly combines artistic functionality and spirituality. This study will explore and analyze it, aiming to analyze the techniques and methods of color application, hoping to provide some reference and value for contemporary painting art creation.