Against the backdrop of globalization and cultural convergence, the homogenization of regional interior design has become increasingly prominent. As an intuitive and emotionally rich design element, color serves as a crucial carrier for the inheritance and expression of regional culture. This paper takes Lingnan traditional dwellings as the research object and explores their interior color design strategies from the perspective of regional culture. Firstly, it analyzes the color cultural genes from the dimensions of natural geographical environment, philosophical thoughts, folk beliefs, and craftsmanship techniques, and explains the characteristics of multiple integration such as "learning from nature", "neutrality and implicitness", and "gorgeousness and simplicity". Then, it dissects the pain points in current practices, including the superficialization of cultural symbols, conflicts in adapting to modern functions, and the lack of scientific support for colors. Finally, it proposes four strategic paths: "color translation of natural imagery", "contemporary embodiment of cultural spirit", "innovative interpretation of technical materials", and "ecological consideration of systematicness and sustainability", aiming to provide theoretical and practical guidance for interior color design with regional characteristics.