Color choices in packaging design have a key impact on the consumer experience, and a large number of product packaging preferences use extremely bright or bright colors to attract attention, but these designs can put a large burden on the eyes and lead to visual fatigue. Packaging layouts that include too many colors or complex combinations can easily distract consumers from key information. Therefore, this paper discusses the specific factors of visual fatigue caused by different color packaging and the interference mechanism caused by different colors of packaging to consumers' attention, in order to provide suggestions for designing more comfortable and efficient information communication.